Proteoglycan was not readily available for many years because of the costly and difficult process of extraction. Recently, a patented effective extraction method for proteoglycan was developed, allowing for this new ingredient to enter the market. While consumers may not be as familiar with proteoglycan, they may be familiar with chondroitin sulfate (a popular joint health supplement). Chondroitin sulfate does not exist naturally in its free form but rather exists in the human body attached to a protein core, which as a whole makes up the protein Proteoglycan. Similar to Type II Collagen, undenatured Proteoglycan in its native form contains active sites that may have specific functional benefits in the human body by targeting inflammation in the joints. Proteoglycan currently has three human studies that show efficacy in decreasing knee pain at very small doses. Proteoglycan has also shown in a human study to improve skin condition by decreasing wrinkles, pores, blotches, and improving skin elasticity and looseness. Non-human studies have shown Proteoglycan to have a wide range of benefits such as reducing the production of the enzyme that degrades cartilage, having immunomodulatory and anti-inflammatory effects, promoting wound healing, stimulating production of new chondrocytes (cells that make proteoglycan and collagen), and more!